Volume 1, Issue 3, November 2006
Dr Ching-Wan LAM, MBChB(CUHK), PhD(CUHK), FRCPA, FHKAM(Pathology)
Associate Professor, Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital
Dr Chloe MAK, MBBS(HK), FRCPA
Resident Specialist, Division of Clinical Biochemistry, Department of Pathology, Queen Mary Hospital
Wilson disease (WD) (MIM # 277900) is an autosomal recessive disorder of copper transport. Clinical manifestations of WD vary widely. The age of onset ranges from three to more than 50 years of age. The initial onset of symptoms can be hepatic, neurological, psychiatric or as an acute haemolytic crisis. The prevalence of WD has been estimated to be approximately 1 in 30,000 in the Caucasian population. Although the prevalence of WD in the Hong Kong Chinese has not been investigated,...