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Topical Update

Molecular diagnostics for breast cancer

Molecular diagnostics for breast cancer


Volume 17, Issue 2, July 2022  (download full article in pdf)


Editorial note:


New molecular techniques have contributed to the ever-expanding armamentarium for breast cancer diagnosis, treatment and prognostication. Since the molecular classification of breast cancer was established, pathologists have been using immunohistochemistry and DNA sequencing techniques to routinely grade and subtype breast cancer. RNA expression profiling using various platforms such as microarrays, quantitative PCR and Nanostring has also been used to guide patient treatment in early diseases. This topical update provides a concise review on the current diagnostic and prognostic modalities in breast cancer management. We welcome any feedback or...

Measurable residual disease (MRD) for Haematological Malignancy

Measurable residual disease (MRD) for Haematological Malignancy


Volume 17, Issue 1, January 2022  (download full article in pdf)


Editorial note:


Measurable residual disease (MRD) monitoring has emerged as an important indicator for risk stratification and treatment planning in patients with haematological malignancies. In the past decade, various techniques in measuring MRD have become available in Hong Kong. In this Topical Update, Dr. YIP Sze-fai provides an overview of the current techniques available for MRD monitoring. We welcome any feedback or suggestions. Please direct them to Dr. Alvin IP of Education Committee, the Hong Kong College of Pathologists. Opinions expressed are those of the authors or named individuals,...

Combined metabolomics and genomics approach for the diagnosis of inherited metabolic disorders (IMD)

Combined metabolomics and genomics approach for the diagnosis of inherited metabolic disorders (IMD)


Volume 16, Issue 2, July 2021  (download full article in pdf)


Editorial note:


In this topical update, Dr Eric Law reviews and updates on the current development in metabolomics and genomics and their integrated approach in the study of inherited metabolic disorders (IMD). We welcome any feedback or suggestions. Please direct them to Dr. Sammy Chen of Education Committee, the Hong Kong College of Pathologists. Opinions expressed are those of the authors or named individuals, and are not necessarily those of the Hong Kong College of Pathologists.



Dr Chun-yiu LAW

Consultant,...

Diagnosis of COVID-19

Diagnosis of COVID-19


Volume 16, Issue 1, January 2021  (download full article in pdf)


Editorial note


Coronavirus disease 2019 (COVID-19) is undoubtedly the most topical subject not only in the medical field, but also for humanity globally. In this issue of the Topical Update, Dr. Derek Hung and Prof. Kwok Yung Yuen present an overview on the diagnosis of COVID-19, which underpins effective disease control. We welcome any feedback or suggestion. Please direct them to Dr. Janice Lo, Education Committee, The Hong Kong College of Pathologists. Opinions expressed are those of the authors or named individuals, and are not necessarily those of the Hong Kong College of Pathologists.



Dr. Derek HUNG and...

Drowning: A Rational Approach to its Diagnosis

Drowning: A Rational Approach to its Diagnosis


Volume 15, Issue 2, July 2020  (download full article in pdf)


Editorial note:


Drowning often presents in various scenarios depending on the circumstances. This Topical Update provides a proper approach to the diagnosis. We welcome any feedback or suggestions. Please direct them to Dr. FOO Ka-chung of Education Committee, the Hong Kong College of Pathologists. Opinions expressed are those of the authors or named individuals, and are not necessarily those of the Hong Kong College of Pathologists.



Dr. FOO Ka-chung

Specialty Coordinator (Forensic Pathology), Education Committee

The Hong Kong College of...

Liver injury associated with immune checkpoint inhibitors - update on clinicopathological features

Liver injury associated with immune checkpoint inhibitors - update on clinicopathological features


Volume 15, Issue 1, January 2020  (download full article in pdf)


Editorial note:


Immune checkpoint inhibitors revolutionize the field of immuno-oncology. They have demonstrated great potential in a wide range of adult cancers by reaching long-lasting objective responses and prolonging survival. Through completed and on-ongoing clinical trials, their indications continue to expand among different cancer types. However, one of their limitations is immune-related adverse events, which are most frequently reported in skin, gastrointestinal tract, and endocrine organs. Immune-related adverse events in liver are less common hepatotoxicity but still...

Recent Advance in Acute Lymphoblastic Leukaemia

Recent Advance in Acute Lymphoblastic Leukaemia

 

Volume 14, Issue 2, August 2019  (download full article in pdf)

 

Editorial note

In this topical update, Dr Albert Sin reviews recent advances in diagnosis and management of acute lymphoblastic leukaemia (ALL).  We welcome any feedback or suggestions. Please direct them to Dr Rock Leung (e-mail: leungyyr.ha.org.hk) of Education Committee, the Hong Kong College of Pathologists. Opinions expressed are those of the authors or named individuals and are not necessarily those of the Hong Kong College of Pathologists.

 

Dr. Albert Sin
Clinical Assistant Professor

 

Introduction

Acute...

Biochemical genetics in the expanded newborn screening era

topical_update_v14i1

Biochemical genetics in the expanded newborn screening era

 

Volume 14, Issue 1 January 2019  (download full article in pdf)

 

Editorial note

In this topical update, Dr. Calvin Chong reviews and updates on the technological development of biochemical genetics for the three major classes of metabolic disorders, namely aminoacidopathies, organic acidurias and fatty acid oxidation defects. These conditions have increasing local awareness, in particular with the introduction of universal expanded newborn screening. With a rising clinical demand for confirmatory tests in biochemical genetics, the ways to achieve better analytical quality and capacity were discussed. We welcome any feedback or suggestions. Please...

Antimicrobial resistance – a global health crisis

Antimicrobial resistance – a global health crisis

 

Volume 13, Issue 2 July 2018  (download full article in pdf)

 

Editorial note

With increasing prominence of the threat of antimicrobial resistance both internationally and locally, awareness and knowledge on the problem and prospects are essential, in order for rational application of control measures and monitoring of their effectiveness. In this issue of the Topical Update, Dr. Dominic Tsang and Dr. Christopher Lai present an updated overview of this important subject. We welcome any feedback or suggestion. Please direct them to Dr. Janice Lo (e-mail: janicelo@dh.gov.hk), Education Committee, The Hong Kong College of Pathologists. Opinions expressed are those of the authors or named...

An overview of NMO Spectrum Disorder and the diagnostic utility of anti-NMO antibodies

An overview of NMO Spectrum Disorder and the diagnostic utility of anti-NMO antibodies

 

Volume 13, Issue 1 December 2017  (download full article in pdf)

 

Editorial note

NMOSD is an immune mediated demyelinating disease. Though its clinical presentation may overlap with multiple sclerosis, distinguishing these two entities is important in view of differences in treatment. Anti-NMO antibodies play a crucial role in the workup and diagnosis of NMOSD. In this review, Dr Elaine Au provided an overview of the NMOSD condition and the use of anti-NMO antibody assays. We welcome any feedback or suggestions. Please direct them to Dr Elaine Au (email: ayl436@ha.org.hk) of Education Committee, the...